The Microbial Maven aka Mary Ruddick
Greetings, my little microbes! Today, we venture into the microscopic galaxy where the tiniest of heroes and villains wage battles that impact our health, vitality, and even our moods. In this microbial Star Wars, some bacteria come in both light and dark sides – two sides of the same species, each distinguished by their substrain numbers, like unique call signs for their role in our microbial universe. Buckle up, as your Microbial Maven takes you on a tour of the bacterial worlds where the same family name can mean friend… or foe.
The Innocents: Bacteria Without a Dark Side
Before we dive into the dual-natured bacteria, let’s first honor those pure-hearted microbes with no “dark side.” These microbes are all beneficial, bringing balance and harmony without a hint of villainy. They’re the peaceful keepers of our microbiome, dedicated to health, protection, and balance. Among these innocents are:
• Lactobacillus reuteri: Known for its powerful health benefits, this species has no pathogenic strains. Strains like Lactobacillus reuteri DSM 17938 support gut health, reduce inflammation, and even increase oxytocin – the “love hormone.” A little hug for your insides, and completely safe.
• Lactobacillus rhamnosus: While incredibly beneficial, especially Lactobacillus rhamnosus GG (ATCC 53103), which supports immunity and gut barrier health, in the rarest cases, it can cause infection in extremely immunocompromised individuals. But outside of these cases, you’re dealing with a pure friend.
Now, onto the true stars of our microbial galaxy – those whose numbers are essential to know. Their light side brings strength, protection, and resilience, but their dark side can wreak havoc if left unchecked.
The Dual-Natured: Microbes with Both Light and Dark Sides
Some microbes straddle the line between good and evil, with certain strains promoting health and others causing harm. These microbes are as nuanced as the most complex characters – with good fighters, bad fighters, and some that can even be swayed to support our health. Here’s a look at these dual-natured species, the good ones you want on your team, and how they can help fend off their more villainous kin.
Escherichia coli (E. coli): The Complex Soldier
The Good:
• Escherichia coli Nissle 1917: This heroic strain, also known as E. coli Nissle 1917, is a true champion for health. It can help balance the microbiome, reduce inflammation, and even fight against pathogenic E. coli. It’s a soldier trained to maintain peace and protect its host.
The Bad:
• Escherichia coli O157:H7: The dark lord of the E. coli family, this strain produces shiga toxins that can cause severe foodborne illness, leading to abdominal pain, vomiting, and in severe cases, kidney failure and death. Found in contaminated food, it’s a force to reckon with.
The Strategy:
E. coli Nissle 1917 (Nissle) is actually able to inhibit pathogenic E. coli, using its beneficial colonization powers to outcompete and neutralize the threat. By taking this “good” E. coli, we can create an internal defense system to fight off the bad. A true Jedi warrior within your gut.
Staphylococcus: The Skin’s Protector vs. The Skin’s Menace
The Good:
• Staphylococcus epidermidis ATCC 12228: A steady protector of the skin’s microbiome, S. epidermidis maintains the skin’s barrier, produces antimicrobial peptides, and even fends off more harmful bacteria. It’s like your skin’s silent sentinel.
The Bad:
• Staphylococcus aureus MRSA USA300: This antibiotic-resistant menace is notorious for causing skin infections, and in serious cases, it can become invasive, leading to sepsis. It’s a true villain, especially dangerous in hospital settings.
The Strategy:
Our friend S. epidermidis can help keep S. aureus in check by maintaining a balanced skin microbiome and producing its own antimicrobials. Though MRSA requires special treatment when active, keeping S. epidermidis strong on your skin is like maintaining a local militia to prevent harmful strains from establishing a foothold.
Clostridium: The Gut’s Firefighter vs. The Gut’s Pyromaniac
The Good:
• Clostridium butyricum MIYAIRI 588: A powerful ally, this strain produces butyrate, which soothes inflammation, heals the gut lining, and supports overall gut health. It’s like the firefighter, keeping inflammation in check.
The Bad:
• Clostridium difficile ATCC 9689: This strain is infamous for causing severe colitis, particularly after antibiotic use. It produces toxins that damage the gut lining, leading to painful and debilitating symptoms.
The Strategy:
Butyrate produced by C. butyricum not only promotes a healthy gut but creates an environment where C. difficile finds it hard to thrive. C. butyricum also strengthens the gut’s immune defenses, making it more difficult for C. difficile to cause issues, especially after antibiotic treatment.
Enterococcus: The Gut’s Helper vs. The Opportunist
The Good:
• Enterococcus faecium SF68: A friendly strain often found in probiotics, E. faecium SF68 supports gut health and helps balance the intestinal microbiome, giving strength to beneficial bacteria and supporting digestion.
The Bad:
• Enterococcus faecalis ATCC 29212: Although this strain can live harmlessly in the gut, it can turn opportunistic, causing urinary tract infections or even endocarditis, especially in immunocompromised individuals.
The Strategy:
Taking beneficial E. faecium strains helps maintain balance, preventing pathogenic strains from overgrowing. When beneficial strains are established, they make it hard for opportunistic strains to take hold, especially in the gut.
The Power of Numbers: Why Identifiers Matter
Now, my little microbes, you see why those numbers after the names are so crucial. Without them, how would you know if you’re dealing with E. coli the defender or E. coli the destroyer? Or if your Staphylococcus is a friendly shield on your skin or an invader? These identifiers – like ATCC 12228 for S. epidermidis or O157:H7 for pathogenic E. coli – are your microbial keycards, distinguishing friends from foes and unlocking the unique benefits of each substrain.
Harnessing the Power of the Light Side
In the microbial world, balance is key. By cultivating beneficial strains, we can often outcompete and crowd out the villains lurking in the same species. This is how the good can “fight” the bad: by staking their claim in the microbiome and fortifying our natural defenses.
So, remember, my little microbes, not all bacteria are created equal – even within the same family. By choosing the right strains, we empower the light side of the microbiome to keep the dark side at bay. Whether you’re cultivating Lactobacillus reuteri for gut health, Staphylococcus epidermidis for radiant skin, or Escherichia coli Nissle 1917 for microbial harmony, you are wielding the microbial force for good.
May the light side of your microbiome be ever in your favor!
A quick lesson on microbes and all those words and numbers after the microbial name:
In microbiological taxonomy, the term “family” is a specific classification level that is broader than “genus” or “species.” Let’s breakdown the following and use human social terms to gain a deeper understanding:
Lactobacillus reuteri DSM 17938:
Lactobacillaceae = Family (Formal reference).
This is the family to which Lactobacillus belongs, grouping it with other genera that share broader characteristics.
In scientific terms, Lactobacillaceae is the actual family, while Lactobacillus is the genus. However, people sometimes refer to the genus as a “family” informally because it functions like a last name, identifying related organisms. I do this often.
Lactobacillus = Genus (aka Informal Familial reference):
This is the next level down and can be thought of as the “family name” in everyday language. The genus groups species that are more closely related and share key traits, like producing lactic acid.
Reuteri = Species (aka Surname).
This identifies the specific organism within the genus Lactobacillus, indicating more precise traits.
DSM: DSM is an identifier for the strain collection where this particular strain is cataloged.
“DSM” stands for Deutsche Sammlung von Mikroorganismen (German Collection of Microorganisms), a prominent microbial repository. This code tells us that this strain has been deposited and registered in the DSMZ (German Collection of Microorganisms and Cell Cultures).
Significance: Strains deposited in collections like DSMZ have undergone rigorous classification and identification, making them standardized for research and commercial use. DSM is a quality marker indicating a reliably identified strain.
17938 = Strain Identifier (aka first name).
If Reuteri is your last name, think of the numbers that follow to be your first name. Now think about how different you are from your siblings. See why these numbers are important?!
This is the unique strain identifier within the species, marking it for specific health effects or functions.
THIS IS THE MOST IMPORTANT ONE TO KNOW.
In summary, Lactobacillus is the genus (family identifier), reuteri is the species, DSM indicates the strain’s repository (where it’s cataloged), and 17938 is the unique strain identifier, specifying this strain’s unique characteristics and health effects.
Citations:
Babalola, O. O. (2010). Beneficial bacteria of agricultural importance. Biotechnology Letters, 32(11), 1559–1570.
Bucci, V., Bradde, S., Biroli, G., & Xavier, J. B. (2012). Social interaction, noise and antibiotic-mediated switches in the intestinal microbiota. arXiv preprint arXiv:1203.2883.
Carding, S., Verbeke, K., Vipond, D. T., Corfe, B. M., & Owen, L. J. (2015). Dysbiosis of the gut microbiota in disease. Microbial Ecology in Health and Disease, 26(1), 26191.
DeGruttola, A. K., Low, D., Mizoguchi, A., & Mizoguchi, E. (2016). Current understanding of dysbiosis in disease in human and animal models. Inflammatory Bowel Diseases, 22(5), 1137–1150.
Gallo, R. L., & Nakatsuji, T. (2011). Microbial symbiosis with the innate immune defense system of the skin. Journal of Investigative Dermatology, 131(10), 1974–1980.
Hullar, M. A. J., Burnett-Hartman, A. N., & Lampe, J. W. (2014). Gut microbes, diet, and cancer. Cancer Treatment and Research, 159, 377–399.
Kim, N., Kim, J. J., Kim, I., Mannaa, M., & Park, J. (2021). Type VI secretion systems of plant-pathogenic Burkholderia glumae BGR1 play a functionally distinct role in interspecies interactions and virulence. Molecular Plant Pathology, 22(1), 58–74.
Latz, E., Eisenhauer, N., Rall, B. C., Scheu, S., & Jousset, A. (2016). Unravelling linkages between plant community composition and the pathogen-suppressive potential of soils. Scientific Reports, 6, 23584.
Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008). A microbial symbiosis factor prevents intestinal inflammatory disease. Nature, 453(7195), 620–625.
Naik, S., Bouladoux, N., Linehan, J. L., Han, S. J., Harrison, O. J., Wilhelm, C., … & Belkaid, Y. (2015). Commensal–dendritic-cell interaction specifies a unique protective skin immune signature. Nature, 520(7545), 104–108.
Ogoshi, A. (1996). Introduction—the genus Rhizoctonia. In Rhizoctonia Species: Taxonomy, Molecular Biology, Ecology, Pathology and Disease Control (pp. 1–9). Springer.
Peters, R. D., Sturz, A. V., Carter, M. R., & Sanderson, J. B. (2003). Developing disease-suppressive soils through crop rotation and tillage management practices. Soil and Tillage Research, 72(2), 181–192.
Raaijmakers, J. M., Paulitz, T. C., Steinberg, C., Alabouvette, C., & Moënne-Loccoz, Y. (2009). The rhizosphere: a playground and battlefield for soilborne pathogens and beneficial microorganisms. Plant and Soil, 321(1–2), 341–361.
Riera, J. L., & Baldo, L. (2020). Microbial co-occurrence networks of gut microbiota reveal community conservation and diet-associated shifts in cichlid fishes. Animal Microbiome, 2(1), 1–14.
Tian, B. Y., Cao, Y., & Zhang, K. Q. (2015). Metagenomic insights into communities, functions of endophytes and their associates with infection by root-knot nematode, Meloidogyne incognita, in tomato roots. Scientific Reports, 5, 17087.